CompletedNot Applicable

Post-stroke Fatigue, Inflammation, tDCS

United States12 participantsStarted 2022-07-12

Plain-language summary

Fatigue is a common condition after an individual has a stroke. While the negative impacts of post-stroke fatigue are well known, the knowledge of the causes of post-stroke fatigue and effective treatments for post-stroke fatigue are lacking. This small study will investigate the possible benefits of transcranial direct current stimulation (tDCS), which uses small electrical currents supplied by a 9-volt battery, on post-stroke fatigue and investigate tDCS' possible anti-inflammatory effects.

Who can participate

Age range35 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Men and women of any race or ethnicity * 35-80 years of age * 6+ months post-stroke * Have clinically present fatigue for 6 months * Able to walk 10m unassisted Exclusion Criteria: * Absolute contraindications to MRI, TMS (transcranial magnetic stimulation), or tDCS (e.g., implanted metal devices, history of seizure, and surgical clips or staples) * Inability to understand and provide written informed consent * Multiple strokes on opposite hemispheres * Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, and dementia) * Severe hypertension * Cerebellar or brainstem strokes/lesions * Concurrent depression and/or anxiety disorders

What they're measuring

Change in Fatigue Severity Scale (FSS) Score

Timeframe: Baseline, post-intervention (2-weeks)

Trial details

NCT IDNCT05330988

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-31

Results submitted2024-10-18

View on ClinicalTrials.gov More Stroke trials