Stopped: The compound is no longer suitable for further clinical development due to a safety finding in a later phase program.
This is a Phase 1 study designed to assess the relative bioavailability (BA), safety and tolerability and PK of the pediatric and adult formulations of branaplam.
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Part 1: Plasma Cmax
Timeframe: Day 1, 2, 3, 4, 5, 8, 11 and 15
Part 1: Plasma AUClast
Timeframe: Day 1, 2, 3, 4, 5, 8, 11 and 15 in each period
Part 1: Plasma AUCinf
Timeframe: Day 1, 2, 3, 4, 5, 8, 11 and 15 in each period
Part 2:Plasma Cmax
Timeframe: Day 1, 2, 3, 4, 5, 8, 11 and 15 in each period
Part 2: Plasma AUClast
Timeframe: Day1, 2, 3, 4, 5, 8, 11 and 15 in each period
Part 2: Plasma AUCinf
Timeframe: Day 1, 2, 3, 4, 5, 8, 11 and 15 in each period