ERAdicate S. Aureus in Patients With Bacteremia and Endocarditis

Inclusion Criteria: * Age of 18 to 90 years * Index blood culture collection within 96 hours prior to enrollment positive for S. aureus * Experienced at least one sign or symptom related to SAB within past 96 hours prior to enrollment * Known or suspected left- and/or right-sided endocarditis by modified Duke criteria and/or known or suspected complicated SAB * Required duration of SOC antibiotic therapy ≤ 42 days Exclusion Criteria: * Previous receipt of LSVT-1701 or CF-301 (exebacase) * Known hypersensitivity to kanamycin or other aminoglycosides * Treatment with any potentially effective (anti-S. aureus) systemic antibiotic for \> 96 hours within 7 days before enrollment. Exception: Persistent S. aureus bacteremia after 96 hours of prior appropriate systemic antistaphylococcal antibiotic, and/or resistance to the prior systemic antibiotic * Treatment with dalbavancin or oritavancin within the previous 90 days * Known or suspected brain abscess or meningitis * Community acquired pneumonia, nosocomial pneumonia because of pathogens other than S. aureus, or known polymicrobial bacteremia * Presence of an intravascular infection source or extravascular material that cannot be removed within 96 hours after enrollment