Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA (NCT05326828) | Clinical Trial Compass
RecruitingNot Applicable
Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA
Switzerland60 participantsStarted 2022-05-24
Plain-language summary
Myocardial infarction with non-obstructive coronary arteries (MINOCA) (i.e.\<50% stenoses) on coronary angiography) is an underappreciated clinical entity concerning 5-6% of patients with acute myocardial infarction. Approximately 50% of these patients remain without appropriate diagnosis and treatment.
The MINOCA study aims at systematically assessing the frequency of underlying pathologies of MINOCA and outcomes with a multidisciplinary etiologic work-up and follow-up of 5 years including, for the first time, an implantable cardiac monitor (ICM) to assess the frequency of atrial fibrillation as underlying cause for MINOCA.
Who can participate
Age range18 Years – 85 Years
SexALL
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Inclusion criteria
✓. ≥18 years of age
✓. Written informed consent
✓. Acute myocardial infarction (AMI) type 1 in accordance with the 4th universal definition of myocardial infarction
✓. Non-obstructive coronary arteries on angiography defined as the absence of coronary artery stenoses ≥50% in any potential infarct-related artery
✓. No clinically overt specific cause for the acute presentation
✓. Subendocardial or transmural late gadolinum enhancement (LGE) consistent with an ischemic etiology on cardiac magnetic resonance imaging (CMR)
✓. No clear underlying cause of MINOCA and therefore increased probability of atrial fibrillation
Exclusion criteria
✕. Known atrial fibrillation or atrial flutter
✕. History of atrial fibrillation or atrial flutter ablation
✕
What they're measuring
1
ICM group: Atrial fibrillation
Timeframe: 1 year
2
Non-ICM group: Frequency of underlying causes of MINOCA