Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors (NCT05326633) | Clinical Trial Compass
Not Yet RecruitingEarly Phase 1
Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors
United States78 participantsStarted 2027-03-01
Plain-language summary
Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly. To address the sequalae of critical illnesses, the investigators will perform a trial incorporating an intervention that combines mobility-based physical rehabilitation (MRP), high protein supplementation (HPRO), and neuromuscular electric stimulation (NMES). The investigators will then assess both clinical and functional outcomes and determine the relationship of disability with systemic inflammation.
Who can participate
Age range60 Years – 99 Years
SexALL
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Inclusion criteria
✓. LTACH admission within 72 hours
✓. Age ≥ 60 years old
✓. Prior ICU stay ≥ 2 weeks
✓. Able to follow commands in English
✓. Pre-ICU Barthel Index ≥ 70
✓. Able to give consent
✓. Able to perform physical therapy
✓. All four limbs intact and mobile prior to LTACH admission
Exclusion criteria
✕. Acute kidney injury with a glomerular filtration rate \<15 ml/min
✕. Diagnosis of severe organ dysfunction including end stage liver disease or cirrhosis