Active — Not RecruitingNot Applicable

Does Caffeine Facilitate Human Reward Learning Behaviors?

Switzerland36 participantsStarted 2022-05-05

Plain-language summary

"Learning from the rewards" is underlying the formulation of knowledge and habits in daily life. Caffeine is the most commonly used "psychoactive" substance that could change one's mind state by affecting the brain and nervous system. By such effects, caffeine enhances reward signals - dopamine - in human brains. In this research study, we will find out whether taking caffeine acutely or daily can enhance reward learning processes.

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 and ≤ 40 * Clinically healthy * Non-smokers Exclusion Criteria: * Habitual caffeine intake \< 100 mg or \> 450 mg * Pregnant or lactating women * Women using hormonal contraceptives * BMI \< 18.5 or \> 29.9 * Sleep disturbance or extreme chronotypes * Nicotine or recreational drug users * Depression, anxiety, psychosis, or neurologic disorders * Severe heart or cardiovascular diseases * Diabetes or metabolic diseases * Under chronic medications * Incapable to operate the tasks or comprehend the study information in German or English * Users of the Bopomo alphates utilized as stimuli in the reward learning tasks * Current enrolment in other clinical trials

What they're measuring

The accuracy (% of correct answers) in implicit learning through different probabilities of monetary reward feedback

Timeframe: 1-hour after the second intake on the 7th day

Trial details

NCT IDNCT05325502

SponsorYu-Shiuan Lin

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-12-31

View on ClinicalTrials.gov More Caffeine trials