Hemodynamic Effect of Topical Anesthesia During Induction in Patients Undergoing Cardiac Surgery (NCT05323786) | Clinical Trial Compass
CompletedNot Applicable
Hemodynamic Effect of Topical Anesthesia During Induction in Patients Undergoing Cardiac Surgery
China96 participantsStarted 2022-04-20
Plain-language summary
Patients scheduled for cardiac surgery are fragile. Hemodynamic fluctuation might be associated with adverse outcomes. Therefore, it is essential to keep hemodynamics stable during and after the induction period. Previous studies have shown that topical anesthesia can provide excellent superior supraglottic and subglottic local anesthetic effects and can significantly reduce the dosage of intravenous anesthetics. Therefore, we designed this study to explore whether the combination of topical anesthesia and intravenous anesthetics could decrease the stress response of endotracheal intubation and keep hemodynamics stable during and after the induction period.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Patients older than 18 years and younger than 75 years;
✓. Patients scheduled to accept elective cardiac surgery;
✓. Patients of New York Heart Association (NYHA) Ⅱ～Ⅲ level grade ;
✓. Patients signed the informed consent form for the clinical study.
Exclusion criteria
✕. Patients cannot cooperate to topical anesthesia;
✕. Patients who had left heart assist devices other than intra-aortic balloon counterpulsation before surgery;
✕. Patients treated with Extracorporeal Membrane Oxygenation (ECMO) prior to surgery;
✕. Patients with aortic dissection;
✕. Patients with difficult airway;
✕. Patients with high sensitivity and hypersensitivity to lidocaine;
What they're measuring
1
The area under the curve of baseline blood pressure
Timeframe: From 3 minutes after endotracheal intubation(T1) to 15 minutes after endotracheal intubation(T2). T1 is defined as 3 minutes after endotracheal intubation. T2 is defined as 15 minutes after endotracheal intubation. It will take up to 1hour or 2hours.