High-definition Transcranial Direct Current Stimulation (HD-tDCS) in Late-life Depression (LLD) (NCT05322863) | Clinical Trial Compass
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High-definition Transcranial Direct Current Stimulation (HD-tDCS) in Late-life Depression (LLD)
Hong Kong58 participantsStarted 2021-02-22
Plain-language summary
To determine the efficacy of a 2-week daily programme (10 sessions) of HD-tDCS to augment antidepressant therapy in subjects with late-life depression who had residual depressive symptoms despite adequate dosage and duration of antidepressant therapy.
Who can participate
Age range60 Years
SexALL
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Inclusion criteria
✓. 60 years of age or above
✓. Right-handedness, as determined by the Edinburgh Handedness Inventory (to homogenise neuroanatomical targeting)
✓. Chinese ethnicity
✓. Fulfil the criteria of Major Depressive Disorder (single or recurrent episode) and in partial remission, defined by the 5th Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5)
✓. Presence of mild to severe level of depressive symptoms measured and defined by HAM-D-17 score ≥8 and ≤ 52\[22\]
✓. Suboptimal treatment response with at least one adequate antidepressant trial defined as full or best tolerated doses at least 6 weeks
✓. Stable dosage of antidepressants or other treatments for depression in recent 4 weeks
✓. Valid informed written consent
Exclusion criteria
✕. A DSM-5 diagnosis other than Depressive Disorders (e.g., bipolar and related disorders, schizophrenia spectrum and other psychotic disorders).
✕. A Hong Kong Chinese version of the Montreal Cognitive Assessment (HK-MoCA) score below the second percentile according to the subject's age and education level (to exclude subjects with existing dementia)
✕. Alcohol or substance dependence
✕
What they're measuring
1
Change in the Depressive symptoms
Timeframe: Assessed at baseline, immediately after the intervention, and 4 and 12 weeks after the intervention.