Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection

Inclusion Criteria: * Age equal or superior to 18 years * Previous history of Clostridioides difficile infection in the 90 days before the study enrolment * Need for hospitalization and need of antibiotic therapy * Signature of informed consent Exclusion Criteria: * Woman of childbearing age, pregnant woman, or breastfeeding woman * Hypersensitivity to vancomycin * Inability to comply with study protocol * Critically ill condition or life expectancy less than 30 days * Patients with diagnosed inflammatory bowel disease or with any conditions that produce chronic diarrhea * Fulfilment of the criteria for diarrhea or diagnosis of CDI at the time of assessment for eligibility or in the previous 3 days * Therapy with oral vancomycin or any other agent with activity against C. difficile for \>48 hours in the previous 3 days;. * Prophylaxis with oral vancomycin or any other agent with activity against C. difficile within the 70 days before the assessment for eligibility * Systemic antibiotic therapy for 72 hours or more before the recruitment * Ongoing enrolment in another RCT evaluating the effectiveness of other drugs * Estimated use of systemic antibiotic therapy for more than 4 weeks