Hyaluronic Gel vs Chlorhexidine in Periodontal Patients

Plain-language summary

This randomized controlled clinical trial (RCT) aims to evaluate the adjunctive efficacy of two domiciliary treatments in patients with periodontitis undergoing non-surgical periodontal therapy. After signing the informed consent, patients satisfying the inclusion criteria will undergo professional supragingival and subgingival periodontal debridement of both arches performed using ultrasonic instrumentation, manual instrumentation with Gracey curettes, and air polishing with glycine powder. After the initial treatment, participants will be randomly allocated into two groups according to the assigned domiciliary therapy: * Aftoral® Oral Gel containing hyaluronic acid, xylitol, and glycerophosphoinositol, applied domiciliary for 15 days. * Unidea® chlorhexidine digluconate mouthwash 0.20%, used as a domiciliary rinse for 15 days. The total duration of the study will be 6 months. Patients will be evaluated at the following time points: Baseline (T0); 1 month after baseline (T1); 3 months after baseline (T2); 6 months after baseline (T3). Professional oral hygiene procedures will be repeated at T2 and T3. At each visit, a patient satisfaction questionnaire regarding the assigned product (taste, smell, consistency, persistence, and ease of application) will be collected. In addition, the following periodontal clinical parameters will be recorded using a periodontal probe at each site: * Gingival Recession (GR) * Probing Pocket Depth (PPD) * Bleeding on Probing (BoP) * Clinical Attachment Level (CAL) * Plaque Control Record (PCR) * Tooth Mobility (TM)

Who can participate

What they're measuring

Trial details