Efficacy of Low-Dose Topical Steroids in Maintaining Remission of Eosinophilic Esophagitis in Chi⦠(NCT05309590) | Clinical Trial Compass
Active ā Not RecruitingNot Applicable
Efficacy of Low-Dose Topical Steroids in Maintaining Remission of Eosinophilic Esophagitis in Children
United States50 participantsStarted 2014-05
Plain-language summary
This study evaluates the decrease in steroid dosing for patients who have achieved remission on a full dose of steroids. Once a patient is in remission they will be enrolled in this study if they choose to decrease the steroid dosing.
Who can participate
Age range1 Year ā 21 Years
SexALL
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Inclusion Criteria:
* Patients diagnosed with EoE
* Patients less than 21 years of age at enrollment
* Patients who within the past 12 months have demonstrated histologic remission (\<15 eos/hpf as assessed by upper esophagogastroduodenoscopy (EGD) with biopsy ) to the standard induction dose of topical steroids and have remained on this treatment:
* Topical steroid treatment includes only those with previously published results: Swallowed topical fluticasone (i.e. FloventĀ®), and Swallowed viscous budesonide (i.e. Pulmicort RespulesĀ®) mixed with Honey or SplendaĀ®
* Patients who are interested in lowering their dose of topical steroids.
Exclusion Criteria:
* Patients with EoE who have not demonstrated histologic remission (\<15 eos/hpf) to topical steroids.
* Patients who are unable or unwilling to take topical steroids.
* Patients who have changed the vehicle or carrier (e.g. Splenda®or honey ) used to mix with the actual steroid drug, after demonstrating histologic remission.
What they're measuring
1
Efficacy of Low Dose Topical Steroid
Timeframe: At standard of care endoscopies from the date of enrollment; estimated every 6-12 months
Trial details
NCT IDNCT05309590
SponsorAnn & Robert H Lurie Children's Hospital of Chicago