Following lung transplantation (LTX), patients may exhibit respiratory and skeletal muscle weakness that will affect exercise capacity, increase dyspnea and fatigue, limit activities of daily living (ADL) and decrease quality of life. Inspiratory muscle training (IMT) has been extensively studied in a variety of non-LTX populations and research has shown that IMT improves exercise capacity, diaphragmatic thickness, and reduced dyspnea during activities of daily living and improved quality of life in patients with advanced lung disease. The aim of this randomized controlled study is to investigate the benefits of providing inspiratory muscle training via use of an inspiratory muscle trainer device in addition to standard physical therapy in the acute phase of rehabilitation following LTX. Patients targeted for enrollment will be those with any type of advanced lung disease requiring LTX with the objective of demonstrating improvements in respiratory muscle recovery, perceived dyspnea, severity of fatigue, and overall functional status following the transplant procedure.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Change in inspiratory muscle strength: Maximal inspiratory pressure (MIP) measured in cmH2O
Timeframe: The groups will be assessed: Before Lung transplantation, at baseline (immediate post-transplant), 8 weeks, 6 and 12 months after LTX
Change in perceived dyspnea: Modified Medical Research Council Dyspnea Scale
Timeframe: The groups will be assessed: Before Lung transplantation, 8 weeks, 6 and 12 months after LTX
Change in fatigue: Fatigue Severity Scale
Timeframe: The groups will be assessed: Before Lung transplantation, 8 weeks, 6 and 12 months after LTX
Change in functional capacity
Timeframe: The groups will be assessed: Before Lung transplantation, 8 weeks, 6 and 12 months after LTX