A Study of OCE-205 in Participants With Cirrhosis With Ascites Who Developed Hepatorenal Syndrome-Acute Kidney Injury

Inclusion Criteria: * Signed informed consent form (ICF) by participant or their legal/authorized representatives. * Diagnosed with decompensated cirrhosis with ascites. * Receiving albumin and has had appropriate diuretic withdrawal for at least 2 days prior to randomization into the study. * Beta-blockers should be discontinued 48 hours prior to randomization, unless doctor deems necessary for appropriate medical treatment. * No sustained improvement in renal function after both diuretic withdrawal and plasma volume expansion with albumin. * Female participants must have a negative pregnancy test prior to randomization and agree to avoid becoming pregnant during the study and for 30 days after the end of treatment. Male participants must agree to use 2 effective contraceptive methods during the study and up to 30 days after the end of treatment. Exclusion Criteria: * Serum Creatinine \>3.8 mg/dL. * Large volume paracentesis (LVP ≥6L) within 4 days of randomization. * Pulse oximeter reading of \<90% on 2L or less. * Sepsis and/or uncontrolled bacterial infection. * Experienced shock within 72 hrs prior to screening. * Model for End-Stage Liver Disease (MELD) score \>35. * Hypertension with a Systolic BP \> 140 mmHg and/ or a Diastolic BP \>100 mmHg. * Treated with or exposed to nephrotoxic agents or has had exposure to radiographic contrast agents within 72 hrs prior to screening. * Has superimposed acute liver injury due to drugs, or toxins except for acute alcoholic hep…