Gut Permeability-related Inflammation and Cardiovascular Disease Risk in Normal-weight and Metabo… (NCT05308394) | Clinical Trial Compass
UnknownNot Applicable
Gut Permeability-related Inflammation and Cardiovascular Disease Risk in Normal-weight and Metabolically Healthy Obesity
United States80 participantsStarted 2022-03-10
Plain-language summary
The investigators are examining the extent gut permeability explains observed inflammation in normal-weight and metabolically healthy obesity (and potentially cardiovascular disease risk).
Who can participate
Age range18 Years – 50 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Control group: normal BMI, body fat percentage \< 25% for men and \< 35% for women, \< 1 of the following: blood pressure \>130/85 mmHg, fasting glucose \>100 mg/dL, fasting triglycerides \>150 mg/dL, HDL cholesterol \< 40 mg/dL (men) or \< 50 mg/dL (women).
* Normal-weight obesity group: normal BMI, body fat percentage \> 25% for men and \> 35% for women.
* Metabolically healthy obesity: BMI \> 30, body fat percentage \> 25% for men and \> 35% for women, and \< 1 of the following: blood pressure \>130/85 mmHg, fasting glucose \>100 mg/dL, fasting triglycerides \>150 mg/dL, HDL cholesterol \< 40 mg/dL (men) or \< 50 mg/dL (women).
* Metabolic syndrome group: BMI \> 30, body fat percentage \> 25% for men and \> 35% for women, and 2 or more of the following: blood pressure \>130/85 mmHg, fasting glucose \>100 mg/dL, fasting triglycerides \>150 mg/dL, HDL cholesterol \< 40 mg/dL (men) or \< 50 mg/dL (women).
Exclusion Criteria:
* Presence of pacemaker
* Pregnant
* Cardiometabolic disease (e.g., diabetes, cardiovascular disease)
* Disease that is inflammatory in nature (e.g., inflammatory bowel disease, rheumatoid arthritis)
* Postmenopausal status
* Use of tobacco products
* Using illicit drugs
* Using lipid lowering drugs