CompletedNot Applicable

Optimizing Cerebral Autoregulation During Surgery

United States27 participantsStarted 2023-01-09

Plain-language summary

The purpose of this study is to conduct a pilot trial to determine the feasibility, safety, and potential efficacy of targeting mean arterial blood pressure (MAP) within the limits of cerebral autoregulation during surgery compared with usual care.

Who can participate

Age range60 Years – 100 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * planned hip or knee surgery (either for fracture or elective) or lung surgery * age ≥60 * ambulatory at baseline * expected duration of surgery \> 90 minutes Exclusion Criteria: * Planned concurrent surgery * Allergy to adhesive tape * Short Blessed Test score \>20 * Clinical diagnosis of dementia * Opinion of either the anesthesiologist or surgeon that the patient is not appropriate.

What they're measuring

Mean Arterial Pressure Outside Limits of Cerebral Autoregulation

Timeframe: Intraoperative, up to 5 hours

Estimated Blood Loss

Timeframe: Intraoperative, up to 5 hours

Number of Participants With New Myocardial Infarction After Surgery

Timeframe: In the hospital after surgery, up to 2 weeks

Number of Participants With New Stroke After Surgery

Timeframe: In the hospital after surgery, up to 2 weeks

Trial details

NCT IDNCT05308290

SponsorJohns Hopkins University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-06-28

Results submitted2025-06-27

View on ClinicalTrials.gov More Hip Fractures trials