Randomized Assessment of Antibiotic Prophylaxis Prior to Port Placement

Inclusion Criteria: * Adult patients requiring TIVAD insertion for long-term central venous access * Patients able to give informed consent to participate in the study. Exclusion Criteria: * taking long-term antibiotics * unable to give consent to participate in the study * Patients that have a known infection at time of the procedure (as documented in e-DH). * Patients with a planned surgical procedure within 30 days of initial TIVAD insertion. * Patients that are currently on antibiotics or have received antibiotics within the last week. * Patients with allergies to cefazolin. * Patients with an absolute neutrophil count of less than 500/mm3 * Women who are pregnant.