Fibrinogen Replacement to Prevent Intracranial Haemorrhage in Ischemic Stroke Patients After Thrombolysis (FibER)

Inclusion criteria: * patients with acute ischemic stroke treated with i.v. thrombolysis (rtPA 0,9 mg/Kg, 10% in bolus and 90% in infusion in 60 minutes) * age \>18 years * critical hypofibrinogenemia post-tPA, defined as a decrease of serum fibrinogen level \<200 mg/dl and/or a rate decrease \>50% than baseline level * written informed consent Exclusion criteria: * contraindication to rtPA treatment; * patients who present symptomatic ICH during infusion of rt-PA, * absence of written informed consent