It is planned to explore the efficacy and safety of local 0.05% cyclosporine eye drops in the treatment of chronic graft-versus-host eye disease. Through the comparative study with 0.1% tacrolimus eye drops, to clarify the short-term and long-term efficacy of 0.05% CSA in these patients, and to explore the benefits of long-term maintenance of local cyclosporine to patients.
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visual acuity
Timeframe: Within 4 hours of initial enrollment
visual acuity
Timeframe: At the first month of enrollment
visual acuity
Timeframe: At the third month of enrollment
visual acuity
Timeframe: At the sixth month of enrollment
Intraocular pressure
Timeframe: Within 4 hours of initial enrollment
Intraocular pressure
Timeframe: At the first month of enrollment
Intraocular pressure
Timeframe: At the third month of enrollment
Intraocular pressure
Timeframe: At the sixth month of enrollment
Ocular Surface Disease Index
Timeframe: Within 4 hours of initial enrollment
Ocular Surface Disease Index
Timeframe: At the first month of enrollment
Ocular Surface Disease Index
Timeframe: At the third month of enrollment
Ocular Surface Disease Index
Timeframe: At the sixth month of enrollment
Corneal fluorescein staining
Timeframe: Within 4 hours of initial enrollment
Corneal fluorescein staining
Timeframe: At the first month of enrollment
Corneal fluorescein staining
Timeframe: At the third month of enrollment
Corneal fluorescein staining
Timeframe: At the sixth month of enrollment
Tear break-up time
Timeframe: Within 4 hours of initial enrollment
Tear break-up time
Timeframe: At the first month of enrollment
Tear break-up time
Timeframe: At the third month of enrollment
Tear break-up time
Timeframe: At the sixth month of enrollment