Health-related Quality of Life, Symptom Severity, and Pain Among Patients With PIK3CA-related Overgrowth Spectrum: A Mixed-methods Observational Study

Inclusion Criteria: Adult patients: * At least 18 years of age * Self-reports having been diagnosed with 1 of the following syndromes: * Klippel-Trenaunay Syndrome (KTS) * Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and spinal (CLOVES syndrome) * Isolated Lymphatic Malformation (ILM) * Megalencephaly-Capillary Malformation (MCAP or M-CM) * Hemimegalencephaly (HME)/Dysplastic Megalencephaly (DMEG)/Focal cortical dysplasia type II * Hemihyperplasia-Multiple Lipomatosis (HHML) * Facial Infiltrating Lipomatosis (FIL) * Fibroadipose Vascular Anomaly (FAVA) * Macrodactyly * Hemihyperplasia (Muscular HH) * Fibroadipose hyperplasia or Overgrowth (FAO) * Capillary malformation of the lower lip, Lymphatic malformation of the face and neck, Asymmetry of the face and limbs, and Partial or generalized Overgrowth (CLAPO syndrome) * Epidermal nevus, benign lichenoid keratosis, or seborrheic keratosis * Able to converse and read/answer survey questions in English * Willing and able to provide informed consent Adolescent patients * Between the ages of 12 and 17 years * Self-reports having been diagnosed with one of the following syndromes: * Klippel-Trenaunay Syndrome (KTS) * Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and spinal (CLOVES syndrome) * Isolated Lymphatic Malformation (ILM) * Megalencephaly-Capillary Malformation (MCAP or M-CM) * Hemimegalenc…