Topical Ruxolitinib in Chronic Hand Dermatitis

Inclusion Criteria: * Diagnosis of chronic hand eczema defined as hand eczema, which has persisted for more than 3 months or returned twice or more within the last 12 months. * Disease severity graded as moderate to severe according to IGA (i.e., IGA ≥2). * Recent history (within 1 year before the screening visit) of inadequate response to topical corticosteroid and/or calcineurin inhibitors treatment or topical corticosteroid treatment being medically inadvisable. Exclusion Criteria: * Active atopic dermatitis in regions other than the hands requiring medical treatment. * Active psoriasis in regions other than the hands requiring medical treatment. * Clinically significant infection (e.g., impetiginized hand eczema or tinea manum) on the hands. * Patients with excessive contact of hands with water (longer than 2 hours at day; or \> 20 hands washing at day) that is believed to be a predominant cause of the hand dermatitis. * Subjects with known antigen sensitization based on Patch test (with 3 years) that are unable to reduce contact with the specific antigen(s). * Subjects chronically and consistently exposed to known-irritant or other substance known to impact skin barrier will be excluded based on PI judgement * Systemic treatment with immunosuppressive drugs, immunomodulating drugs, retinoids, or corticosteroids within 4 weeks prior to baseline. * Systemic treatment with antibiotics within 4 weeks prior to baseline * Phototherapy on the hands within 4 weeks prior to ba…