The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.
Who can participate
Age range18 Years – 30 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* History of COVID-19 vaccination
* Weigh at least 110 pounds
Exclusion Criteria:
* Colorblindness
* Inability to hear verbal instructions
* Cardiovascular disease, including a history of stroke
* Diabetes requiring the use of insulin
* Pregnancy
* Current asthma (an asthma attack within the past five years)
* Medications for or history of anxiety disorder diagnosis or panic attacks
* Medications which may affect cognition such as beta-blockers and CNS depressants
Temporary Exclusion Criteria
* Respiratory symptoms in the previous four weeks
* Use of sedating cold/allergy medications in the previous week
* Use of marijuana in the previous week
* Consumption of alcohol in the previous 24 hours
Additional Exclusion Criteria for Subjects undergoing the fMRI scan:
* History of head trauma or neurosurgery or neurological disorder
* Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry
* Surgical pins or plates above the neck
* History of eye injury involving metallic materials, shavings in eyes, or welding without a face mask
* Lead or iron tatoos
* Claustrophobia
* Back problems that would prevent the subject from laying still comfortably for up to 90 minutes
Additional Exclusion Criteria for Subjects undergoing CAIM
* Current or recent contact lens use
What they're measuring
1
Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Basal Oxygen Consumption (OCR)
Timeframe: 4 hours after each exposure
2
Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Total Stimulated Oxygen Consumption.
Timeframe: 4 hours after each exposure
3
Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Time to Peak (TTP) Oxygen Consumption
Timeframe: 4 hours after each exposure
Trial details
NCT IDNCT05292378
SponsorRutgers, The State University of New Jersey