Immunogenicity of Fractional Dose of the HPV Vaccines

Inclusion Criteria: * Age 27-45 years at enrollment * Not intending to receive the HPV vaccine series for the duration of the study participation * Willing and able to: provide written informed consent, undergo clinical evaluation, adhere to follow-up schedule Exclusion Criteria: * Prior immunization with HPV-vaccine (Cervarix, Gardasil-4, Gardasil-9) * Currently pregnant or breastfeeding * Immunedeficiency disease/condition or cancer that causes clinically significant immunosuppression * Known HIV infection * Chemotherapy (current or within 12 months) or currently taking a medication that causes clinically significant immunosuppression. * Unstable medical condition (e.g., malignant hypertension, poorly controlled diabetes) * Known allergy to vaccine components * Prior history of HPV-associated cancer * Any medical condition which, in the opinion of the investigator, may compromise the subject's ability to safely complete the study.