Boluses of Ringer's in Surgical Kids (BRiSK Study) (NCT05285371) | Clinical Trial Compass
CompletedEarly Phase 1
Boluses of Ringer's in Surgical Kids (BRiSK Study)
United States70 participantsStarted 2022-02-22
Plain-language summary
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar. The basic tenets include: (1) Continuous intravenous fluid administration; (2) Total fluid volume based on the "4:2:1" rule; (3) Use of hypotonic electrolyte solutions, most commonly 0.45% sodium chloride (NaCl) + 20 milliequivalents per liter (mEq/L) potassium chloride (KCl); and (4) Inclusion of 5% dextrose to increase the osmolarity of the infusate and to help prevent ketosis and acidemia.
Who can participate
Age range1 Year ā 21 Years
SexALL
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Inclusion criteria
ā. Males or females age 12 months to 21 years.
ā. Weight \>= 8 kg.
ā. Patients with an uncomplicated abdominal or thoracic surgical procedure in which the expected postoperative length of stay is anticipated to be at least 2-5 days.
ā. Patients admitted to a regular bed following surgery.
ā. Patients who will be inpatient for approximately 4-8 days postoperatively.