Up to 60% of patients admitted to the Intensive Care Unit (ICU) with a prolonged stay in the ICU develop complications such as intensive care unit acquired weakness (ICUAW) characterized by limb and respiratory muscle weakness. ICUAW is associated with worse prognosis, longer ICU stay and increased morbidity and mortality. Physical therapy (PT) interventions in the intensive care unit (ICU), can improve patients' outcomes. However, improvements in muscle function achieved with standard physical activity interventions aiming at early mobilization are highly variable due to lack of consistency in definition of the interventions, lack of consideration for the complexity of exercise dose and/or insufficient stimulation of muscles during interventions. It has been suggested that modifying early mobilization and exercise protocols towards shorter intervals consisting of higher intensity exercises might result in more optimal stimulation of muscles. In the present study the researchers therefore aim to simultaneously assess (by non-invasive technologies) locomotor muscle oxygenation and activation along with the measurements of the load imposed on respiration and circulation during two different training modalities i.e., moderate intensity continuous bed-cycling (endurance training) vs high-intensity alternated by lower intensity periods of bed-cycling (interval training).
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Differences between bed-cycling protocols in fractional oxygen saturation (StiO2,%) for each measured region of the m. quadriceps femoris
Timeframe: constant-load and interval bed-cycling protocols administered in 2 different days within 1 week
Differences between bed-cycling protocols in activation (sEMG amplitude) for each measured region of the muscle quadriceps femoris
Timeframe: constant-load and interval bed-cycling protocols administered in 2 different days within 1 week
Adverse event rate during constant-load bed-cycling
Timeframe: 1 session of maximal 20 minutes of constant-load bed-cycling per patient
Adverse event rate during interval bed-cycling
Timeframe: 1 session of maximal 20 minutes of interval bed-cycling per patient
Percentage of completed constant-load bed-cycling sessions
Timeframe: 1 session of maximal 20 minutes of constant-load bed-cycling per patient
Percentage of completed interval bed-cycling sessions
Timeframe: 1 session of maximal 20 minutes of interval bed-cycling per patient