CompletedPhase 2/3

Leukocyte and and Platelet-rich Fibrin Plasma for the Prevention of Anastomotic Leakage in Colorectal Anastomosis

Chile106 participantsStarted 2018-03-12

Plain-language summary

Anastomotic leak rate in colorectal surgery is estimated between 4 and 20 percent. Leukocyte and and platelet-rich fibrin plasma (L-PRF) is second generation platelet concentrate whose application in colorectal anastomosis in animals has shown promising results that suppose a lower leakage rate. The objective of this study was to assess the feasibility of using L-PRF in colorectal surgery and to determine the incidence of anastomotic leakage after colorectal anastomosis.

Who can participate

Age range15 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients were submitted to elective colorectal anastomosis with mechanic anastomosis on or under the peritoneal reflection. * Postoperative evaluation using contrast enema to objectify subclinical dehiscence. Exclusion Criteria: * Age under 15 years * American Association of Anesthesiologists (ASA) grade IV or higher. * Clinical signs of peritonitis * Other major surgeries within 30 days of the procedure. * Deficient nutritional state (defined by plasmatic albumin levels lower tan 2.8 mg/dl) Active treatment with corticoids and the impossibility of having contrast enema post-surgery.

What they're measuring

Determine the incidence of anastomotic leakage after colorectal anastomosis

Timeframe: 30 days

Trial details

NCT IDNCT05264467

SponsorUniversidad de Concepcion

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-07-09

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