The purpose of this study is to assess the safety, tolerability, drug levels, and preliminary efficacy of relatlimab plus nivolumab in pediatric and young adult participants with recurrent or refractory classical Hodgkin lymphoma and non-Hodgkin lymphoma.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Incidence of dose-limiting toxicities (DLTs)
Timeframe: Up to 135 days following last dose
Maximum tolerated dose or Recommended phase 2 dose (MTD/RP2D)
Timeframe: Up to 135 days following last dose
Number of participants with Adverse Events (AEs)
Timeframe: Up to 135 days following last dose
Number of participants with serious adverse events (SAEs)
Timeframe: Up to 135 days following last dose
Number of participants with AEs leading to discontinuation
Timeframe: Up to 135 days following last dose
Number of deaths
Timeframe: Up to 2 years from the last treatment of last participant
Number of participants with clinical laboratory abnormalities
Timeframe: Up to 135 days following last dose
Maximum observed plasma concentration (Cmax)
Timeframe: Up to 96 weeks
Trough observed concentration (Ctrough)
Timeframe: Up to 96 weeks
Time of maximum observed plasma concentration (Tmax)
Timeframe: Up to 96 weeks
Area Under the Curve within a dosing interval (AUC(TAU))
Timeframe: Up to 96 weeks
Complete Metabolic Response (CMR) Rate defined as the proportion of all response-evaluable participants who achieve the best response of CMR using Lugano 2014 criteria
Timeframe: Up to 2 years from the last treatment of last participant