Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas

Inclusion Criteria: Inclusion Criteria AGE: ≥ 18 years of age Weight: \>30 kg Life expectancy of at least 12 weeks Part A and B (Phase 1): Patients with histologically confirmed soft tissue or bone sarcoma of the following subtypes: * MFH/ undifferentiated pleomorphic sarcoma * Unclassified sarcoma * Rhabdomyosarcoma * Malignant peripheral nerve sheath tumor (MPNST) * Osteosarcoma * Ewing or Ewing-like sarcoma * Synovial sarcoma * Desmoplastic small round blue cell tumor (DSRCT) Patients must have progressed or demonstrated disease that is refractory to standard therapies. Patients for whom no standard of care treatments exist are eligible. Part C (Phase 2): Patients with progressive, relapsed, unresectable or metastatic NF associated MPNST. MEASURABLE DISEASE: Patients must have evaluable or measurable disease (Phase 1) and measurable disease by RECISTv1.1 (Phase 2). * Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering on this study excluding chronic grade 1 toxicities and alopecia. * No limitation on the number of prior chemotherapy regimens that the patient may have received prior to study entry. * Myelosuppressive chemotherapy: The last dose of all myelosuppressive anticancer drugs must be at least 3 weeks (≥21 days) and 42 days if prior nitrosourea prior to study entry. * Immunotherapy: The last dose of immunotherapy (monoclonal antibody or vaccine) must be at least 4 weeks …