Cardiac Imaging in Adults With Congenital Aortic Stenosis (NCT05252351) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Cardiac Imaging in Adults With Congenital Aortic Stenosis
Netherlands75 participantsStarted 2022-01-13
Plain-language summary
The CAS study is a prospective observational cohort study investigating the effects of congenital aortic stenosis (ConAoS) on the left ventricular function and the prevalence, pattern and expanse of left ventricular hypertrophy (LVH), myocardial stiffness and myocardial fibrosis.
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
In order to be eligible to participate in this study, a subject must meet the following criteria:
* Aged ≥ 18 years
* Capable of understanding and signing informed consent.
Inclusion criteria for the CAS study are patients diagnosed with a valvular congenital aortic stenosis. Two groups of patients will be included:
* Patients with a prior aortic valve replacement (AVR)
* Patients without a prior AVR and with an aortic jet velocity ≥ 2.5 m/s.
Exclusion Criteria:
* Patients with severe aortic regurgitation
* Presence of any of the following contra-indications for MRI
* Contra-indication to gadolinium based contrast media (eGFR \<30 ml/min or contrast allergy)
* Other contra-indications such as presence of pacemaker/implantable cardioverter defibrillator, severe claustrophobia or pregnancy
* Patients known with or previously treated because of aortic coarctation.
* Patients known with genetic syndromes or connective tissue disorders