Assessment of Patients With Acute Pouchitis Treated With Antibiotics

Inclusion Criteria: * Adult patients ≥ 18 years of age * IPAA for UC (J-pouch only) ≥ 6 months prior to screening * Diagnosis of acute pouchitis at screening by stool frequency (an absolute value of ≥ 6 stools / day AND an increase of ≥ 3 stools / day above the post-IPAA baseline), and local endoscopy (presence of ≥ 1 erosion or ulceration of the pouch on endoscopy \[not including ulceration occurring within 1 cm of the pouch staple or pouch suture line\]). * Not currently taking antibiotics for pouchitis or previous systemic antibiotic use for any reason within 4 weeks of screening. Prior to the Screening pouchoscopy. Note: Initiation of antibiotics for treatment of acute pouchitis prior to the Screening pouchoscopy will be permitted only if the participant initiates treatment within 48 hours prior to the Screening pouchoscopy; use outside of the 48-hour window will not be permitted and these patients should not be included in the study * Current treatment with 5-aminosalicylic acid drugs, immunosuppressants, antidiarrheals, antimotility agents, and probiotics is permitted, if patient has received a stable dose for ≥ 4 weeks prior to screening. Dose of concomitant therapy must remain stable during the study period. * Able to participate fully in all aspects of this clinical trial. * Written informed consent must be obtained and documented Exclusion Criteria: * Pouch formations besides J-pouch (e.g., W-, S- and Kock pouches). * IPAA for familial adenomatous polyposis. * Po…