CompletedNot Applicable

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

United States20 participantsStarted 2022-04-26

Plain-language summary

The purpose of this study is to compare clinical outcomes after mechanical debridement of at sites exhibiting plaque induced inflammation with or without adjunctive Antimicrobial photodynamic therapy (aPDT) and to assess the the microbiologic profile before and after treatment with or without aPDT

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * One pocket on each side of the mouth (split design) * Single rooted tooth * Pocket depths measured greater than 4mm with bleeding on probing * Horizontal bone loss * No furcation involvement Exclusion Criteria: * current heavy smokers (\>10 cigarettes/day) * have uncontrolled diabetes (HbA1c ≥ 6.5%) * other uncontrolled systemic diseases that may comprise healing, such as Vitamin C deficiency, any neutrophil deficiencies, immunodeficiency syndromes, or leukemia * taking antibiotics within 3 months before the procedure * vertical bone defects that requires surgical regenerative treatment. * Pregnancy

What they're measuring

Change in Number of Bleeding Sites (Bleeding On Probing)

Timeframe: baseline, at the re-evaluation appointment(4 to 6 weeks after baseline)

Change in Number of Bleeding Sites (Bleeding On Probing)

Timeframe: baseline, 3 months after baseline

Change in Probing Depth (Periodontal Pocket Depth )

Timeframe: baseline, at the re-evaluation appointment (4 to 6 weeks after baseline)

Change in Probing Depth (Periodontal Pocket Depth )

Timeframe: baseline, 3 months after baseline

Trial details

NCT IDNCT05252000

SponsorThe University of Texas Health Science Center, Houston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-10

Results submitted2026-01-22

View on ClinicalTrials.gov More Periodontal Diseases trials

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Change in Number of Bleeding Sites (Bleeding On Probing)

Timeframe: baseline, at the re-evaluation appointment(4 to 6 weeks after baseline)

Change in Number of Bleeding Sites (Bleeding On Probing)

Timeframe: baseline, 3 months after baseline

Change in Probing Depth (Periodontal Pocket Depth )

Timeframe: baseline, at the re-evaluation appointment (4 to 6 weeks after baseline)

Change in Probing Depth (Periodontal Pocket Depth )

Timeframe: baseline, 3 months after baseline