Comparing Chemoprevention Approaches for School-based Malaria Control

Inclusion Criteria: Students (enrolled in the primary intervention) * Currently enrolled in the study school * Plan to attend the study school for the remainder of the school year * Parent/guardian available to provide written informed consent Household members (enrolled in the Household Prevalence survey) * Slept in the household for most nights in the last month * Age 6 months or older * For minors, parent/guardian available to provide written informed consent Exclusion Criteria: Students (enrolled in the primary intervention) * Current evidence of severe malaria or danger signs * Known adverse reaction to the study drugs * History of cardiac problems or fainting * Taking medications known to prolong QT * Family history of prolonged QT * Girls 10 years old and older with epilepsy or psoriasis Household members (enrolled in the Household Prevalence survey) * Household with more than one school-age child enrolled in the study * Current evidence of severe malaria or danger signs