The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) after the patient has received a drug that makes the heart work harder provide clinically important information about the severity of suspected coronary artery disease compared to CT imaging performed without using the drug that causes the heart to work harder.
Who can participate
Age range18 Years – 99 Years
SexALL
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Inclusion Criteria:
* Patients referred for coronary artery cardiac CT imaging or nuclear medicine or MRI cardiac perfusion within the Department of Radiology or Cardiology.
* Patients who are able and willing to sign the informed consent will be enrolled
* Negative pregnancy test if subject is of child-bearing age (females of child-bearing potential will be screened for pregnancy using a urine pregnancy test, which will be administered by the unit study coordinator at no cost to the patient).
Exclusion Criteria:
* Patients unable to provide written informed consent
* Pregnancy
* eGFR ≤ 30
* History of prior moderate or severe contrast reaction includes: unresponsiveness, severe respiratory distress, convulsions, arrhythmia, cardiopulmonary distress, progressive angioedema, laryngeal edema, dyspnea, bronchospasm, symptomatic tachycardia, symptomatic bradycardia, hypotension, hypertensive crisis.
* Any history of required premedication prior to iodinated contrast administration.
* Patients that consent to participation but do not undergo their clinically-indicated, contrast-enhanced CT, or nuclear medicine or MR perfusion scanning for any reason (e.g., bad IV, infiltration, reaction, change in indication).
* Patients experiencing atrial fibrillation, premature ventricular contractions or other heart rhythm abnormalities
* Hospitalized patients or patients under care in the Emergency Department
Specific exclusion criteria only for participation in the cardiac stress test ar…
What they're measuring
1
Change in disease status or post-exam recommendations
Timeframe: Through completion of CT exam, approximately 1 day