A Clinical Pharmacological Study of MT-3921 in Subjects With HTLV-1 Associated Myelopathy (HAM)

Inclusion Criteria: Additional screening criteria check may apply for qualification: * Subjects aged 20 years or older on the day of consent * Subjects with a confirmed diagnosis of HAM according to the diagnostic algorithm of Practical Guideline for HAM 2019 on the day of consent * Subjects with an Osame's motor disability score (OMDS) of ≥4 and ≤6 at Screening and on the first day of the Treatment period (predose) * Subjects with no change in OMDS for at least 3 months before the day of consent * Subjects with a CSF concentration neopterin of ≥6 pmol/mL at Screening * Subjects on maintenance oral steroid therapy who have continued to receive the same dose equivalent to ≤10 mg/day of prednisolone for at least 3 months before the day of consent Exclusion Criteria: Additional screening criteria check may apply for qualification: * Subjects who have a history of anaphylaxis or clinically significant allergic reactions due to administration of antibody products * Subjects exhibiting or with a history of malignant tumor. * Subjects with adult T-cell leukemia/lymphoma (ATL) or those with positive HTLV-1 clonality test (Southern blot) at screening and suspected of having ATL * Subjects with spinal cord compression lesions, such as cervical spine disease, disc herniation, and ossification of the yellow ligament * Subjects with psychiatric disorders, epileptic seizures, or dementia. * Subjects with suicide attempts or suicidal ideation corresponding to item 4 or 5 on the Columbi…