The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age (NCT05234203) | Clinical Trial Compass
CompletedNot Applicable
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
United States50 participantsStarted 2022-03-25
Plain-language summary
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
Who can participate
Age range18 Years – 85 Years
SexALL
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Inclusion Criteria:
* Men and women of any ethnicity.
* Age Range - 18 - 85 (inclusive)
* Participant must be able to comply with treatment plan and laboratory tests including ability and willingness to perform home venous blood draw using Tasso device.
* Participant must be able to read, write and speak English fluently
* Participant must have an established primary care provider
* Participant must be willing and able to consume 4 capsules per day throughout the duration of study period
Exclusion Criteria:
* History or presence of cancer in the prior 2 years, except for non-melanoma skin cancer.
* Known immune system issues or immunodeficiency disease
* History of viral illness which could be reactivated by immune downregulation
* Presence of clinically significant acute or unstable cardiovascular and cerebrovascular (stroke) disease
* Diagnosis of a transient ischemic attack in the 6 months prior to screening
* Participants infected with hepatitis C or HIV
* Body Mass Index (BMI) greater than or equal to 40 kilograms per meter squared
* Presence of active infection in previous 4 weeks
* Any other illness, psychiatric disorder, alcohol or chemical dependence that in the opinion of the Clinical Investigator would render a participant unsuitable to participate in the study
* Unable or unwilling to provide required blood sample for testing
* Current or previous use of known prescription immunomodulating products (e.g. glucocorticoids, tumor necrosis factor (TNF)-alpha inhibi…