Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults

Inclusion Criteria: * Age ≥18 * Diagnosed as having CRS * Undergone at least 2 trials of medical treatments in the past * Mean 3 cardinal symptom (3CS) score * Bilateral ethmoid disease confirmed on CT * Has been informed of the nature of the study and provided written informed consent * Agrees to comply with all study requirements * If on a waiting list for sinonasal surgery, willing to be removed from list or have surgery date cancelled for the duration of the study. Exclusion Criteria: * Inability to tolerate topical anesthesia or endoscopic procedure * Previous nasal surgery * Presence of nasal polyp grade 2 or higher * Seasonal allergic rhinitis * Perennial rhinitis with symptoms that are well controlled by regular use of intranasal corticosteroids * Severe asthma * History or clinical evidence or suspicion of invasive fungal sinusitis, allergic fungal rhinosinusitis, atrophic rhinitis, or odontogenic sinusitis * Obstruction preventing proper placement and retention of LYR-210 as seen on endoscopy * Anatomic variation that, in the opinion of the investigator, would adversely impact placement of LYR-210 as seen on CT * Known history of hypersensitivity or intolerance to corticosteroids * Known history of hypothalamic pituitary adrenal axial dysfunction * Previous pituitary or adrenal surgery * Dental procedure/implant on maxillary dentition within 4 weeks of the Screening visit. * Past or present acute or chronic intracranial or orbital complications of CRS * History o…