Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)
United States77 participantsStarted 2022-02-15
Plain-language summary
The purpose of this study is to compare the effects of three on-line wellness interventions for improving physical and cognitive function and brain connectivity in adults who are at least 55 years old and are experiencing symptoms of memory and/or cognitive difficulties.
Who can participate
Age range55 Years
SexALL
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Inclusion Criteria:
* age ≥ 55 years
* subjective cognitive complaints, defined as self-experienced persistent decline in cognitive capacity in comparison with a previously normal status and unrelated to an acute event
* Montreal Cognitive Assessment (MoCA) score suggestive of Mild Cognitive Impairment (MCI) status (i.e., \< 26)
* English language fluency
* Wireless internet connection at home
* Willingness to travel to the San Francisco VA in northern California or UCLA in southern California for in-person assessments at baseline, after the 12-week interventions, and at the 36-week follow-up
* Capacity to provide informed consent or legally authorized representative consent and participant assent.
Exclusion Criteria:
* current or past Axis I psychiatric disorders, or recent unstable medical or neurological disorders
* disabilities that prevent participation in on-line movement classes (e.g., primarily use wheel-chair, severe visual impairment that would limit ability to observe instructor's movement on screen or severe hearing impairment that would limit ability to hear instructor's directions)
* insufficient English proficiency
* limited life expectancy (i.e., enrolled in hospice, metastatic cancer)
* plan to travel for \> 1 week during 12-week intervention period
* diagnosis of dementia per the DSM-5
* MoCA score suggestive of dementia (i.e., \<17)
* started dementia medication (cholinesterase inhibitor or memantine) in past 3 months or plans to start dementia medicatio…
What they're measuring
1
Change in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) Scores
Timeframe: Change from baseline to 1-week post-treatment.
2
Change in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) Scores
Timeframe: Change from baseline to 6 months after treatment ends.
3
Change in Default Mode Network (DMN) functional connectivity
Timeframe: Change from baseline to 1-week post-treatment.