Evaluation of the Efficacy of Diclofenac Potassium and Rimegepant for the Acute Treatment of Migraine

Inclusion Criteria: * Subject has provided informed consent prior to initiation of any study-specific activities/procedures. * Aged 18 to 65 years upon entry into screening * History of migraine (with or without aura) for greater than or equal to 12 months before screening according to the ICHD-3 criteria based on medical records and/or patient self-report. * Not more than 12 attacks per month with moderate to severe headache pain in each of the previous 3 months. Exclusion Criteria: Disease Related * Greater than 50 years of age at migraine onset * History of cluster headache or hemiplegic migraine headache * Inability to differentiate between migraine from other headaches * Has taken medication for acute treatment of headache (including acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), triptans, ergotamine, opioids, or combination analgesics) on 10 or more days per months in the previous 3 months * Has a history of migraine aura with diplopia or impairment of levels of consciousness, hemiplegic migraine, or retinal migraine. * Required hospital treatment of a migraine attack 3 or more times in the previous 6 months. Other Medical Conditions * The subject is at risk of self-harm or harm to others as evidenced by past suicidal behavior * Has a chronic non-headache pain condition requiring daily pain medication * Has a history of any prior gastrointestinal conditions (e.g., diarrhea syndromes, inflammatory bowel disease) that may affect the absorption or meta…