RecruitingNot Applicable

HepHospital: A Pilot Trial of a Hepatology Home Hospital Intervention for Patients With Advanced Liver Disease

United States30 participantsStarted 2025-07-21

Plain-language summary

This research study is evaluating a program that entails a healthcare at home intervention for people with advanced liver disease.

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

✓. Adult patients ≥ 18 years old with diagnosis of cirrhosis based on histology, radiology, and/or elastography presenting to the emergency department or inpatient general medicine service
✓. Patients must have one of the following:
✓. Ascites (requiring diuretics or serial large volume paracenteses)
✓. Hepatic hydrothorax (requiring diuretics)
✓. Hepatic encephalopathy (requiring medications)

✕. History of solid organ transplantation
✕. On hemodialysis
✕. MELD score \> 20
✕. Score \<10 on Simplified Animal Naming Test (S-ANT1)
✕. Current admission for hemodynamically significant GI bleeding or alcohol withdrawal
✕. Require routine administration of controlled substances
✕. Those deemed ineligible based on the MGH Home Hospital, inpatient medicine or hepatology clinician evaluation

Escalation Rate

Timeframe: 18 months

NCT IDNCT05205954

SponsorMassachusetts General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12-31

Nneka Ufere, MD, MSCE