Active — Not RecruitingPhase 4

Intravenous Vs. Intraosseous Vascular Access During Out-of-Hospital

Denmark1,479 participantsStarted 2022-03-01

Plain-language summary

The "Intravenous vs. Intraosseous Vascular Access During Out-of-Hospital Cardiac Arrest (IVIO)"-trial is an investigator-initiated, randomized, parallel group, patient and outcome assessor-blinded, superiority trial of intravenous vs. intraosseous vascular access during adult out-of-hospital cardiac arrest. The intraosseous group will be further randomized to humeral vs. tibial access. The trial will be conducted in the Central Denmark Region. The primary outcome will be sustained return of spontaneous circulation, and 762 patients will be included. Key secondary outcomes include survival at 30 days and survival at 30 days with a favorable neurological outcome.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Out-of-hospital cardiac arrest
✓. Age ≥ 18 years
✓. Indication for intravenous or intraosseous vascular access during cardiac arrest

Exclusion criteria

✕. Blunt or penetrating traumatic cardiac arrest
✕. Prior enrollment in the trial
✕. Intravenous or intraosseous vascular access already in place and working when the first trial-participating unit arrives on site

What they're measuring

Sustained return of spontaneous circulation

Timeframe: Before or after hospital arrival (up to 2 hours after the cardiac arrest)

Trial details

NCT IDNCT05205031

SponsorLars Wiuff Andersen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-05

View on ClinicalTrials.gov More Cardiac Arrest trials