Wharton's Jelly Eye Drops in the Treatment of Chronic Keratitis

Inclusion Criteria: * Men or women between 18 and 70 years old. * Persistent corneal ulceration. * Resistance to medical treatment for more than one month or recurrence after medical treatment. * Patient who underwent a wash-out period of 15 days with no use of eye drops with preservative. * Patient with dry eye treatments that can be kept: tear substitutes, cyclosporine. * Informed and consenting patient. * Patient affiliated to a social security system or beneficiary of such a system. Exclusion Criteria: * Patient with active infectious or traumatic keratitis such as burns. * Patient with herpetic keratitis. * Patient currently wearing contact lens, including scleral lenses concomitant with the treatment. * Patient currently treated with NSAIDs in eye drops or any eye drops containing preservatives. * Patient treated with antibiotic, anti-viral or anti-parasitic eye drops; with autologous or allogeneic serum; with platelet derivatives; with eye drops claiming healing properties; with eye drops containing growth factors, hyaluronic acid or trehalose. * Patient with hypersensitivity to fluorescein. * Patient with identified causes for keratitis for which discontinuation of medical treatment is beneficial. * Monophthalmic patients. * Persons deprived of liberty by a judicial or administrative decision. * Adults who are subject to a legal protection measure or who are unable to express their consent. * Pregnant woman.