Effects of LSD on Neuroplasticity in Healthy Subjects (NCT05177419) | Clinical Trial Compass
CompletedPhase 1
Effects of LSD on Neuroplasticity in Healthy Subjects
Switzerland45 participantsStarted 2022-05-02
Plain-language summary
Neuroplasticity is the brain's ability to reorganize itself and adapt in response to changing environmental conditions or pathological stimuli. LSD is a potent psychedelic drug which has been able to rapidly stimulate neuroplasticity in animal studies. Various authors have speculated that changes in neuroplasticity may contribute to LSD's long-term effects, but there is still little direct evidence that LSD or other psychedelics enhance neuroplasticity in humans. The goal of this study is to investigate the effects of LSD on several measures of neuroplasticity in healthy human subjects.
Who can participate
Age range21 Years – 55 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Aged 21-55
✓. Body mass index 18-29
✓. Right-handed as assessed by the Edinburgh Handedness Inventory (score \> 60)
✓. Fluent understanding of German
✓. Willingness to adhere to study protocol
✓. Willingness to refrain from taking illicit psychoactive substances for the duration of the study
✓. Willingness to refrain from consuming alcohol for 24 hours before each study appointment.
✓. Willingness to not operate a motor vehicle or other heavy machinery 48 hours after each substance administration.
Exclusion criteria
✕. Severe chronic or acute medical condition
✕. History of any seizure disorder, stroke, or cardiovascular illness
✕. History of severe head trauma resulting in loss of consciousness
✕. Personal or family history (first-degree relative) of psychotic disorders
✕. Current or previous major neurological or psychiatric disorder within the last 3 years (e.g. major depression, anorexia, substance use disorder),
✕
What they're measuring
1
Change in motor evoked potential amplitude after paired associative stimulation (PAS)