Prospective Electronic Polygenic Risk Study - Second Phase (NCT05175651) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Prospective Electronic Polygenic Risk Study - Second Phase
10,000 participantsStarted 2023-06
Plain-language summary
This study will investigate the role of polygenic risk scores (PRS) in preventive health.
Who can participate
Age range45 Years – 65 Years
SexALL
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Inclusion Criteria:
* 45 ≥ Age \< 65
* ASCVD Risk Score \> 7.5% as defined by the standard pooled cohort equation
* Access to and ability to use a smartphone
Exclusion Criteria:
* Prior diagnosis of coronary disease as defined by prior myocardial infarction (STEMI or NSTEMI), or revascularization (stent or coronary artery bypass grafting)
* Prior diagnosis or treatment of glaucoma
* Cerebrovascular disease with history of ischemic stroke, TIA, carotid endarterectomy, carotid artery stenting
* Peripheral arterial disease with history of claudication, revascularization (stents or bypass)
* Current and active high-intensity statin prescription (rosuvastatin 20 mg, rosuvastatin 40 mg, atorvastatin 40 mg and atorvastatin 80 mg)
* Anti-PCSK9 therapy
* Lipid apheresis therapy
* Currently enrolled in a clinical trial for lipid lowering therapy
* Known statin intolerance to 2 or more statins in the past
What they're measuring
1
Composite MACE in intermediate to high clinical risk population