Living Donor Liver Transplantation for CRC Liver Metastases

Recipient Inclusion Criteria In order to be eligible to participate in this study, a potential recipient must meet all of the following criteria prior to transplant procedure: * General inclusion criteria: * Male or female, aged 18 - 65 years old inclusive, at study entry * Willing and able to provide written informed consent * Reside in the United States * Negative serum pregnancy test for women of childbearing potential * Cancer-related inclusion criteria: * Eastern Cooperative Oncology Group (ECOG) : 0 or 1 at all times prior to LDLT * Biopsy-proven colorectal LM * Tumor must have the following characteristics * Non-resectable LM (by consensus of three hepatobiliary (HPB) surgeons). All potential recipients will be presented at Multidisciplinary Tumor Rounds for discussion of treatment options * Synchronous or Metachronous disease * R0 resection can be achieved by total hepatectomy * Primary CRC tumor stage is ≤T3 and ≤N2 * Oslo score of 0-1. The Oslo Score summarizes 4 negative predictive factors for overall survival after liver transplantation for CRLM where each factor is assigned 1 point; maximal diameter of the largest lesion \>5.5 cm, pre-transplant CEA level \>80 μg/L, progressive disease at time of liver transplant and interval from diagnosis to transplant \<2 years * The patient has undergone first-line "standard of care" chemotherapy for a minimum of 3 months (at the time of screening), with demonstrated stability or reg…