PERSEVERE- A Trial to Evaluate AMDS in Acute DeBakey Type I Dissection

Inclusion Criteria: * ≥18 years of age or ≤80 years of age (male or female) at time of surgery * Acute DeBakey type I dissection based on computed tomography angiography (CTA) and diagnosed ≤14 days from of the index event * Presence of malperfusion (cerebral, visceral, renal, spinal cord, and/or peripheral) Exclusion Criteria: * Other medical condition that is associated with limited life expectancy \<2 years (e.g., cancer, congestive heart failure) * Pregnant or breastfeeding. * Unwilling to comply with the follow-up schedule * Institutionalized due to administrative or judicial order * Unwilling to accept blood transfusions for any reason * Coronary malperfusion * In circulatory shock (i.e., systolic blood pressure \<90 mmHg) at time of screening * In extreme hemodynamic compromise requiring cardiopulmonary resuscitation at time of screening * Suspicion of bowel necrosis (as determined by the implanting physician based on imaging observations, peritoneal signs, surgical exploration, elevated serum lactate levels, low pH, and/or acidosis) * Clinical or radiographic signs of bowel infarction or gastrointestinal hemorrhage * Base deficit \> -10 mmol/L or -10 mEq/L * American Society of Anesthesiologists risk class V (i.e., moribund patient not expected to live 24 hours with or without operation) or class VI (a declared brain dead patient whose organs are being removed for donor purposes) * Previous placement of a thoracic endovascular graft * Interventional and/or open sur…