The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.
Who can participate
Age range
12 Years – 24 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
For EIA patients
Inclusion Criteria:
* written agreement
* age \>=12 and \<= 24
* known exercise induced asthma
* Group 1: skin prick test positiv house-dust allergy, eNO \> 30 ppb, MCT PD20 \< 0,1 mg
* Group 2: skin prick test negative house-dust allergy, eNO \< 20 ppb, MCT PD20 \< 1 mg
* lung function before ECC forced vital capacity (FVC) ≥ 75% and forced exspiratory pressure in one second (FEV1) ≥ 70%
Exclusion Criteria:
* age \< 12 und \> 24 years
* lung function FVC \< 75% und FEV1\< 70%
* inability to understand the range of the study
* chronic asthma with systemic cortisone therapy
* regular therapy with inhalative corticosteroids or leukotriene-antagonists \<14 days before visit 1
* intake of long acting beta-agonists (LABA) 48 h before examination
* intake of short acting beta-agonists (SABA) 8 h before examination
* acute severe infection (pneumonia) within the last 4 weeks
* other chronic diseases or infections (HIV, Tbc)
* pregnancy
For healthy controls
Inclusion Criteria:
* written agreement
* age \>=18 and \<= 24
Exclusion Criteria:
* age \< 18 and \> 24 years
* known asthma bronchiale or other chronic lung diseases
* lung function FVC \< 90% and FEV1 \< 80%
* allergic sensitization in skin prick test
* eNO \> 30 ppb
* inability to understand the range of the study
* acute severe infection (pneumonia) within the last 4 weeks
* other chronic diseases or infections (HIV, Tbc)
* pregnancy
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.