Imaging Biomarkers in Spastic Paraplegia Type 5

Inclusion criteria * At least 18 years of age * Signature of the informed consent * Covered by social security * SPG5 patients identified with two mutations in the CYP7B1 gene Exclusion criteria * Contra-indications to MRI (claustrophobia, metallic or material implants) * Additional psychiatric or neurological conditions / additional major comorbidities * History of severe head injury * Participation in another trial (except observational trial) * Pregnancy and breastfeeding * Inability to understand information about the protocol * Persons under AME * Persons deprived of their liberty by judicial or administrative decision * Adult subject under legal protection or unable to consent * Unwillingness to be informed in case of abnormal MRI