Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects

Inclusion Criteria: * Male and female subjects ages 2 to 17 years with clinical diagnosis of chronic plaque psoriasis and stable disease for at least 3 months prior to the baseline visit * Subject with plaque psoriasis covering ≥ 3% of the BSA at screening and baseline * A PGA score of ≥ 2 at screening and baseline * Female subjects of childbearing potential who are engaging in sexual activity that could lead to pregnancy should use acceptable birth control methods * Must not be pregnant * Subject, subject's parent, or legal representative must be capable of giving written informed consent/assent Exclusion Criteria: * Psoriasis other than plaque variant * Any sign of infection of any of the psoriatic lesions * Immunocompromised at screening * Screening alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥2.0x the upper limit of normal (ULN) * Screening total bilirubin \> 1.5x ULN * Current or chronic history of liver disease * Current or history of cancer within 5 years except for adequately treated cutaneous basal cell carcinoma, squamous cell carcinoma or carcinoma in situ of the cervix * Major surgery within 8 weeks prior to baseline or has a major surgery planned during the study * Known history of clinically significant drug or alcohol abuse in the last year prior to baseline * Use of any prohibited medication or procedure within the indicated period before the baseline visit until the completion of the study completion or study discontinuation * Histor…