Practical Anemia Bundle for SusTained Blood Recovery

Inclusion Criteria: * Provision of signed and dated informed consent form (may be completed by legal proxies for those patients unable to provide consent, i.e. sedation/intubation) * Stated willingness to comply with all study procedures and availability for the duration of the study, including follow-up assessments * Current ICU admission at Mayo Clinic Rochester with anticipated ICU duration \>48 hours after enrollment * Current ICU duration \< 7 days * Patients embedded in the local or regional Mayo Clinic Health System to facilitate post-hospitalization outcome assessment * Moderate-to-severe anemia (i.e. hemoglobin concentration \< 10 g/dL) at the time of enrollment, with the hemoglobin concentration assessed no more than 24 hours prior to enrollment. If RBC transfusion has been administered between the qualifying hemoglobin assessment and enrollment, a repeat hemoglobin will be required prior to enrollment to ensure that it remains \< 10 g/dL. Exclusion Criteria: * Recent or current IV iron or erythropoiesis stimulating agent (ESA) use (i.e. darbepoetin, Aranesp, erythropoietin, Epogen, Procrit, Retacrit) within 30 days of enrollment * Severe anemia prior to hospitalization (i.e. hemoglobin \<9 g/dL within 90 days of admission) * Known allergic reactions to iron or EPO * Inability to complete outcome assessments (i.e. not expected to survive hospitalization, unable to make follow-up appointments, non-ambulatory, dementia or other severe cognitive impairment, visual i…