Practical Anemia Bundle for SusTained Blood Recovery
United States100 participantsStarted 2021-11-30
Plain-language summary
The purpose of this study is to test a multi-faceted anemia treatment plan to reduce the severity of anemia and to promote hemoglobin and functional recovery in adults who have been in the intensive care unit (ICU).
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Provision of signed and dated informed consent form (may be completed by legal proxies for those patients unable to provide consent, i.e. sedation/intubation)
* Stated willingness to comply with all study procedures and availability for the duration of the study, including follow-up assessments
* Current ICU admission at Mayo Clinic Rochester with anticipated ICU duration \>48 hours after enrollment
* Current ICU duration \< 7 days
* Patients embedded in the local or regional Mayo Clinic Health System to facilitate post-hospitalization outcome assessment
* Moderate-to-severe anemia (i.e. hemoglobin concentration \< 10 g/dL) at the time of enrollment, with the hemoglobin concentration assessed no more than 24 hours prior to enrollment. If RBC transfusion has been administered between the qualifying hemoglobin assessment and enrollment, a repeat hemoglobin will be required prior to enrollment to ensure that it remains \< 10 g/dL.
Exclusion Criteria:
* Recent or current IV iron or erythropoiesis stimulating agent (ESA) use (i.e. darbepoetin, Aranesp, erythropoietin, Epogen, Procrit, Retacrit) within 30 days of enrollment
* Severe anemia prior to hospitalization (i.e. hemoglobin \<9 g/dL within 90 days of admission)
* Known allergic reactions to iron or EPO
* Inability to complete outcome assessments (i.e. not expected to survive hospitalization, unable to make follow-up appointments, non-ambulatory, dementia or other severe cognitive impairment, visual iā¦