A Study of Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy.

Inclusion Criteria: * Age at the date of signing the informed consent form (ICF): * Arm 1 and Arm 2: ≥ 18 years * Participants diagnosed with AML based on WHO 2016 classification (Arber et al 2016) who are ineligible for standard induction chemotherapy and: * Arm 1 : have received at least 2 cycles and not more than 4 cycles of first-line venetoclax plus azacitidine treatment and have not achieved a CR, CRi, CRh or MLFS. * Arm 2 : newly diagnosed AML with adverse genetic risk stratification (according to ELN 2022) (except TP53 mutation positive participants). * Participant (in both arms) must be considered ineligible for standard of care intensive induction chemotherapy defined by the following: * 75 years of age; OR * 18 to 74 years of age with at least one of the following co-morbidities: Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 or 3; Cardiac history of congestive heart failure (CHF) requiring treatment or Ejection Fraction ≤ 50% or chronic stable angina; DLCO ≤ 65% or FEV1 ≤ 65%. * Participants must have an ECOG performance status: 0 to 2 for participants ≥ 75 years of age. OR 0 to 3 for participants ≥ 18 to 74 years of age. * WBC \< 25x109/L * AST and ALT ≤ 3 × ULN * Estimated Glomerular Filtration Rate (eGFR)≥ 60 mL/min/1.73 m2 Exclusion Criteria: * Prior exposure to MDM2-inhibitor therapy at any time. * Participants with TP53 mutation positive. * Participants with del17p. * Participants with AML-M3 / APL (Acute promyelocytic l…