Risk and Benefits of Electronic Cigarettes to Older Smokers at High Risk for Lung Cancer

Inclusion Criteria: * Aged 50-80 years who currently smokes at least 1 or more combustible cigarettes per day OR who is a nondaily smoker (any self-reported smoking in the past 30 days) with a 20 pack-year history. * Being interested in trying ECs to change CC smoking behavior * Willing to have biospecimen samples taken, either in-home using a mobile phlebotomoty service, or at an approved collection site * Have an address where he/she can receive mail * Being fluent in spoken and written English * Agrees to comply with all MD Anderson institutional policies related to COVID-19 screening prior to any in-person research visit. * The individual agrees to not engage in study procedures or interactions with study personnel while operating a vehicle. Exclusion Criteria: * Individuals who report depressive symptoms in the moderately severe or severe range on the PHQ-9 (scores of 15 or above); or who report current suicidal ideation on the PHQ-9 * Have ever had a diagnosis of lung cancer, have uncontrolled or unstable medical condition (e.g., uncontrolled hypertension, angina, diabetes) * Unwilling to consent for blood draw * Evidence of cognitive deficits or instability that would preclude reliable study participation * Being pregnant, engaging in breast-feeding, or being of childbearing potential and engaging in sexual activity that could lead to pregnancy and is not protected by a medically acceptable, effective method of birth control while enrolled in the study, as determine…